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COMPLEMENT C3B
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DeCS
Descriptor
English
:
Complement C3b
Descriptor
Spanish
:
Complemento C3b
Descriptor
Portuguese
:
Complemento C3b
Tree Number:
D12.776.124.486.274.250.260
Definition
English
:
The larger fragment generated from the cleavage of
COMPLEMENT C3
by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and
COMPLEMENT C5
CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in
IMMUNE ADHERENCE REACTION
and enhances
PHAGOCYTOSIS
. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as
COMPLEMENT C3C
;
COMPLEMENT C3D
; C3e; C3f; and C3g.
Indexing Annotation
English
:
/antag: consider
COMPLEMENT C3B INACTIVATOR PROTEINS
Pharmacological Action:
Immunologic Factors
See Related
English
:
Receptors, Complement 3b
History Note
English
:
2006 (1978)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22315
Unique Identifier:
D003179
Occurrence in VHL
:
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